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UID:20250918T202558EDT-66641w1gEE@132.216.98.100
DTSTAMP:20250919T002558Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ÉçÇø Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Alyson Fou
 rnier\n\n\n\n	Corticospinal circuits and neuropathic pain in chronic CNS in
 jury\n\n\nEdmund Hollis\n\n\n	Director\, Circuit Repair Lab\, Burke Neurolo
 gical Institute / Assistant Professor of Neuroscience\, Weill Cornell Medi
 cine\n\n\nAbstract: Chronic neuropathic pain is a persistent and debilitat
 ing outcome of traumatic central nervous system injury\, affecting up to 8
 0% of individuals. Post-injury pain is refractory to treatments due to the
  limited understanding of the brain-spinal cord circuits that underlie pai
 n signal processing. The corticospinal tract (CST) plays critical roles in
  sensory modulation during skilled movements and tactile sensation\; howev
 er\, a direct role for the CST in injury-associated neuropathic pain is un
 clear. Here we show that complete\, selective CST transection at the medul
 lary pyramids leads to hyperexcitability within lumbar deep dorsal horn an
 d hindlimb allodynia-like behavior in chronically injured adult male and f
 emale mice. Chemogenetic regulation of CST-targeted lumbar spinal interneu
 rons demonstrates that dysregulation of activity in this circuit underlies
  the development of tactile allodynia in chronic injury. Our findings shed
  light on an unrecognized circuit mechanism implicated in CNS injury-induc
 ed neuropathic pain and provide a novel target for therapeutic interventio
 n.\n\nBio: Edmund Hollis\, PhD\, performed his graduate and postdoctoral t
 raining at the University of California\, San Diego with Mark H. Tuszynski
 \, MD\, PhD and Yimin Zuo\, PhD\, respectively. He became Director of the 
 Circuit Repair Laboratory at the Weill Cornell Medicine (WCM) affiliate Bu
 rke Neurological Institute (BNI) in 2015 and Assistant Professor of Neuros
 cience at WCM in 2016. He has received several research awards and was a r
 ecipient of a 2017 NIH Director’s New Innovator Award. Dr. Hollis served a
 s the BNI Postdoctoral Advancement Advisor from 2021-2025\, WCM IACUC Chai
 r since 2025\, and as a post-hoc member on multiple NIH study sections. Hi
 s laboratory studies neural circuit control over movement using a variety 
 of experimental approaches including genetic manipulations\, 2-photon imag
 ing\, optogenetic and chemogenetic control\, and novel behavioral paradigm
 s. In collaboration with Justin Brown\, MD\, at Massachusetts General Hosp
 ital\, he is building on his pre-clinical studies to improve motor recover
 y in individuals with nerve transfer surgery to treat chronic spinal cord 
 injury.\n
DTSTART:20251021T200000Z
DTEND:20251021T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: Corticospinal circuits and neuropathic pain 
 in chronic CNS injury
URL:/neuro/channels/event/killam-seminar-series-cortic
 ospinal-circuits-and-neuropathic-pain-chronic-cns-injury-367155
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