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UID:20250513T153943EDT-5436lwuU9P@132.216.98.100
DTSTAMP:20250513T193943Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ÉçÇø Univers
 ity.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, clic
 k here\n\n\nFranck Polleux\n\nProfessor of Neuroscience\, Columbia Univers
 ity\n\nHost: eric.shoubridge [at] mcgill.ca (Eric Shoubridge )\n\nAbstract
 : Two of the most striking distinguishing features of human cortical pyram
 idal neurons (CPNs) are: (1) human CPNs receive significantly more excitat
 ory and inhibitory synapses than any other mammalian species including non
 -human primates and (2) synaptic development is strikingly neotenic in hum
 ans\, taking years to reach maturation compared to weeks or months in othe
 r mammalian species. Our lab identified two human-specific gene duplicatio
 ns called SRGAP2B/C which\, by inhibiting all known functions of the post-
 synaptic ancestral protein SRGAP2A\, leads to slower (neotenic) rates of e
 xcitatory (E) and inhibitory (I) synaptic maturation and increased E and I
  synapse number. We also demonstrated that this increased density of E syn
 apses in layer 2/3 cortical pyramidal neurons (CPNs) originates from incre
 ased cortico-cortical connections\, leading to changes in the coding prope
 rties of these neurons in vivo and improved behavioral performance in a se
 nsory discrimination task in mice humanized for SRGAP2C expression. I will
  summarize recent results demonstrating (1) the function of human-specific
  genes SRGAP2B/C as critical modifiers of synaptic development in human ne
 urons using xenotransplantation and (2) that SRGAP2B/C also act as human-s
 pecific disease modifiers in the context of neurodevelopmental disorders.
 \n
DTSTART:20241112T210000Z
DTEND:20241112T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Human-Specific Modifiers of Cortical Circuit
 s Evolution
URL:/neuro/channels/event/killam-seminar-series-human-
 specific-modifiers-cortical-circuits-evolution-359673
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