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UID:20250805T002447EDT-0365xn74vp@132.216.98.100
DTSTAMP:20250805T042447Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at the MNI and 91ÉçÇø Universit
 y.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, click 
 here\n\n\nJi-Young Youn\, PhD\n\nScientist\, SickKids Research Institute\,
  Assistant Professor\, University of Toronto\, Canada\n\nHost: gary.armstr
 ong [at] mcgill.ca (Gary Armstrong)\n\nAbstract: Amyotrophic lateral scler
 osis (ALS) is a neurodegenerative disease with no known cure. A hallmark o
 f ALS is the cytoplasmic aggregation of TAR DNA-binding protein 43 (TARDBP
 \, called TDP-43 here). TDP-43 is an essential DNA/RNA-binding protein wit
 h multiple roles in post-transcriptional regulation. Harboring prion-like 
 domain\, TDP-43 readily phase separates in vitro and localizes to biomolec
 ular condensates formed by cellular phase separation. Aberrant phase trans
 ition of TDP-43\, accelerated by ALS-associated mutations or stress\, are 
 thought to underly ALS pathogenesis. However\, the functional consequences
  of altering TDP-43 phase separation properties remain poorly understood. 
 In this talk\, I will share our efforts to characterize ALS-associated TDP
 -43 variants with altered phase separation dynamics. Exploiting proximity-
 dependent biotinylation techniques\, we examine quantitative changes in pr
 oximal interaction networks of TDP-43 variants or TDP-43 wildtype during s
 tress. Our preliminary data reveal unanticipated functions of TDP-43 contr
 olled by phase separation.\n
DTSTART:20240227T210000Z
DTEND:20240227T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Chasing Shape-Shifting Condensates Linked to
  ALS with Proteomics
URL:/neuro/channels/event/killam-seminar-series-chasin
 g-shape-shifting-condensates-linked-als-proteomics-355223
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