BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250803T230246EDT-1866h3KACp@132.216.98.100 DTSTAMP:20250804T030246Z DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro' s Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at the MNI and 91ÉçÇø Universit y.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, click here\n\n\nHelen Bateup\, PhD\n\nAssociate Professor\, Department of Molecu lar & Cell Biology\, UC Berkely\, USA\n\nHost: j-francois.poulin [at] mcgi ll.ca (Jean-François Poulin)\n\nAbstract: Dopamine neurons represent a sma ll fraction of neurons in the brain\, yet they exert widespread influence over a variety of brain systems that control motor function\, reward\, mot ivation\, and learning. Recent work from our lab and others has uncovered considerable diversity within the dopaminergic system\, which likely under lies its pleotropic functions. Importantly\, dysfunction of different clas ses of dopamine neurons contribute to neuropsychiatric and neurodegenerati ve disorders. In this talk\, I will present our work investigating the mol ecular pathways that regulate dopaminergic function. In particular\, I wil l discuss our findings showing that mTOR\, a central regulator of cell gro wth and metabolism\, is a key modulator of dopamine neuron structure and f unction. I will present data from mouse models showing that balanced mTOR activity is critical for proper dopaminergic output\, as suppression or ov eractivation of mTOR has detrimental effects on multiple aspects of dopami ne neuron biology. In addition\, I will discuss our ongoing collaborative work to investigate the pathways that contribute to dopamine neuron degene ration in the context of Parkinson’s disease\, using functional genomics a pproaches in human midbrain organoids.\n DTSTART:20240416T200000Z DTEND:20240416T210000Z LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University SUMMARY:Killam Seminar Series: Molecular Mechanisms Controlling Dopamine Ne uron Biology in Health and Disease URL:/neuro/channels/event/killam-seminar-series-molecu lar-mechanisms-controlling-dopamine-neuron-biology-health-and-disease-3551 50 END:VEVENT END:VCALENDAR