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UID:20250802T051645EDT-3863e833IU@132.216.98.100
DTSTAMP:20250802T091645Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université 91ÉçÇø. \n\n\nPour
  assister en personne\, inscrivez-vous ici\n\nPour regarder via Vimeo\, cl
 iquez ici\n\n\nFranck Polleux\n\nProfesseur de neurosciences\, Université 
 de Columbia\n\nHôte: eric.shoubridge [at] mcgill.ca (Eric Shoubridge )\n\n
 Abstract: Two of the most striking distinguishing features of human cortic
 al pyramidal neurons (CPNs) are: (1) human CPNs receive significantly more
  excitatory and inhibitory synapses than any other mammalian species inclu
 ding non-human primates and (2) synaptic development is strikingly neoteni
 c in humans\, taking years to reach maturation compared to weeks or months
  in other mammalian species. Our lab identified two human-specific gene du
 plications called SRGAP2B/C which\, by inhibiting all known functions of t
 he post-synaptic ancestral protein SRGAP2A\, leads to slower (neotenic) ra
 tes of excitatory (E) and inhibitory (I) synaptic maturation and increased
  E and I synapse number. We also demonstrated that this increased density 
 of E synapses in layer 2/3 cortical pyramidal neurons (CPNs) originates fr
 om increased cortico-cortical connections\, leading to changes in the codi
 ng properties of these neurons in vivo and improved behavioral performance
  in a sensory discrimination task in mice humanized for SRGAP2C expression
 . I will summarize recent results demonstrating (1) the function of human-
 specific genes SRGAP2B/C as critical modifiers of synaptic development in 
 human neurons using xenotransplantation and (2) that SRGAP2B/C also act as
  human-specific disease modifiers in the context of neurodevelopmental dis
 orders.\n
DTSTART:20241112T210000Z
DTEND:20241112T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Human-Specific Modifiers of Cortical Circuit
 s Evolution
URL:/neuro/fr/channels/event/killam-seminar-series-hum
 an-specific-modifiers-cortical-circuits-evolution-359673
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