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UID:20250804T210707EDT-18688jsKm2@132.216.98.100
DTSTAMP:20250805T010707Z
DESCRIPTION:Grâce à la générosité des fiducies Killam\, Le Neuro convoque l
 ors d’une série de séminaires des conférenciers d’exception dont les trava
 ux passionnent ses chercheurs et ceux de l’Université 91ÉçÇø. \n\n\nPour p
 articiper en personne\, inscrivez-vous ici\n\nPour visionner la diffusion 
 sur Vimeo\, cliquez sur le lien suivant\n\n\nJi-Young Youn\, PhD\n\nCherch
 euse\, Institut de recherche SickKids\, Professeure adjointe\, Université 
 de Toronto\, Canada\n\nHôte: gary.armstrong [at] mcgill.ca (Gary Armstrong
 )\n\nAbstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative 
 disease with no known cure. A hallmark of ALS is the cytoplasmic aggregati
 on of TAR DNA-binding protein 43 (TARDBP\, called TDP-43 here). TDP-43 is 
 an essential DNA/RNA-binding protein with multiple roles in post-transcrip
 tional regulation. Harboring prion-like domain\, TDP-43 readily phase sepa
 rates in vitro and localizes to biomolecular condensates formed by cellula
 r phase separation. Aberrant phase transition of TDP-43\, accelerated by A
 LS-associated mutations or stress\, are thought to underly ALS pathogenesi
 s. However\, the functional consequences of altering TDP-43 phase separati
 on properties remain poorly understood. In this talk\, I will share our ef
 forts to characterize ALS-associated TDP-43 variants with altered phase se
 paration dynamics. Exploiting proximity-dependent biotinylation techniques
 \, we examine quantitative changes in proximal interaction networks of TDP
 -43 variants or TDP-43 wildtype during stress. Our preliminary data reveal
  unanticipated functions of TDP-43 controlled by phase separation.\n
DTSTART:20240227T210000Z
DTEND:20240227T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Chasing Shape-Shifting Condensates Linked to
  ALS with Proteomics
URL:/neuro/fr/channels/event/killam-seminar-series-cha
 sing-shape-shifting-condensates-linked-als-proteomics-355223
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