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DTSTAMP:20250924T195027Z
DESCRIPTION:\nFor the very first time\, we are dedicating an entire day to 
 advancing knowledge on focal cortical dysplasia in epilepsy—exploring it a
 cross every level\, from molecular mechanisms to systems. The program will
  include two keynote lectures to set the stage\, dedicated trainee session
 s with posters and oral presentations\, and the highlight of the day\, the
  Pierre Gloor Lecture\, delivered by Stéphanie Baulac (Inserm\, Paris Brai
 n Institute)\, a leading expert in the genetics of epilepsy and neurodevel
 opmental disorders.\n\n\nRegistration coming soon.\n\n\nThe Pierre Gloor L
 ecture celebrates the life and legacy of Pierre Gloor (1923–2003)\, who jo
 ined The Neuro (Montreal Neurological Institute-Hospital) in 1952 as a fel
 low in electroencephalography and neurophysiology. He trained under Wilder
  Penfield and Herbert Jasper and earned his Ph.D. from 91ÉçÇø i
 n 1957. Gloor collaborated closely with clinical and research teams at The
  Neuro in advancing the understanding and treatment of epilepsy\, gaining 
 international recognition for his contributions to the field\n\n\n\n	\n		Prog
 ramme\n		Abstract Submissions\n		Speakers\n		Location\n		Sponsors\n		Scientific Comm
 ittee\n	\n	\n\n	\n		Thursday\, May 28\, 2026\n\n		Please note that the below is a
  preliminary schedule. \n\n		\n			\n				\n					10:00\n					Registration\n				\n				\n					10:15\n					Tours\n				\n
 				\n					11:20\n					\n						Welcome and Introduction\n					\n				\n				\n					11:30\n					\n						Keynote Lectures\n					\n				\n
 				\n					1:00\n					\n						Lunch and Poster Session\n					\n				\n				\n					2:00\n					Oral Presentations\n				\n				\n					3:
 00\n					Refreshment Pause\n				\n				\n					3:15\n					\n						Pierre Gloor Lecture\n\n						Brain Mosaicism
  in Epilepsies and Cortical Malformations\n							Stéphanie Baulac\n							Research Dire
 ctor\, Inserm\, Group Leader\, MOSAIC Team\, Paris Brain Institute (ICM)\n
 					\n				\n				\n					4:15\n					Panel Discussion\n				\n				\n					5:00\n					\n						Cocktail\n					\n				\n			\n		\n	\n	\n\n	\n		Abstra
 ct Submissions\n\n		We invite trainees at the undergraduate\, graduate\, and
  postdoctoral level to present their work as posters. Abstracts will also 
 be considered for oral presentations.\n\n		We encourage you to share your mo
 st current project in any stage of development\, including literature revi
 ews\, research questions\, and pilot projects.\n\n		Submit Your Abstract Her
 e.\n\n		The deadline for abstract submissions is March 23\, 2026\n	\n	\n\n	\n		Sp
 eakers\n\n		Stéphanie Baulac\n\n		Bio: Stéphanie Baulac is a Research Director
  at Inserm and Group Leader at the Paris Brain Institute (ICM) of the MOSA
 IC Team « Genetic Mosaicism in Epilepsy and Neurodevelopmental Disorders »
  Her team implements a comprehensive translational approach spanning from 
 the identification and characterization of somatic mutations in brain tiss
 ues obtained from patients undergoing epilepsy surgery to in-depth functio
 nal analysis\, combining functional testing on patient-derived brain organ
 oids\, and mouse models.\n\n		Lecture Abstract: Focal cortical dysplasia typ
 e II (FCDII) is a cortical malformation causing refractory epilepsy\, resu
 lting from developmental somatic mutations in mTOR pathway genes. To under
 stand how these mutations create a mosaic pattern of affected cells and le
 ad to cortical dyslamination\, we performed comprehensive single-nucleus a
 nalyses of surgical samples from genetically-characterized FCDII patients.
  By combining genotyping and transcriptomics at single-cell resolution\, w
 e revealed that mutations predominantly affect glutamatergic neurons and a
 strocytes\, creating distinct transcriptional programs in both mutated and
  non-mutated cells. This mosaicism drives cell-type-specific dysregulation
  of synaptic and neurodevelopmental pathways that likely contribute to epi
 leptogenesis. Notably\, our analysis of cytomegalic cells uncovered pronou
 nced alterations in mitochondrial metabolism pathways and cellular senesce
 nce. We uncover a signature associated with cellular senescence in abnorma
 l FCDII cells and further provide evidence in preclinical FCDII mouse mode
 ls that senolytic agents could offer a novel therapeutic strategy for this
  disorder.\n\n		\n	\n	\n\n	\n		Location\n\n		The Montreal Neurological Institute an
 d Hospital is at 3801 University Street\, north of Pine Avenue West\, on t
 he 91ÉçÇø campus opposite the former Royal Victoria Hospital.\n
 \n		Montreal is served by highway Routes 10\, 15\, 20 and 40\, and by Greyho
 und Bus\, Via Rail and the P-E-Trudeau airport. In the city\, bus and metr
 o service is provided by the Société de transport de Montréal (STM).\n\n		Wh
 eelchair access\n\n		A wheelchair accessible entrance is on University Stree
 t north of the main entrance. Another wheelchair accessible entrance is in
  the loading area behind the building: to enter the loading area\, turn in
 to the driveway south of the main entrance. Please note\, there is no park
 ing in the loading area.\n\n		Parking\n\n		Parking near the MNI is sometimes d
 ifficult. There are parking meters on University Street and a parking lot 
 north of the main entrance. To enter the lot\, turn right into the drivewa
 y toward Molson Stadium.\n\n		Information about parking fees\n\n		Taxi Stand\n
 \n		There is a taxi stand on University Street across from the main entrance
 . You may call a cab from the free taxi phone in the main lobby near the S
 ecurity Desk.\n\n		Access by Public Transportation (STM website)\n\n		Bus\n\n		T
 here are four bus stops within walking distance:\n\n		\n			Bus 144 stops at Pin
 e Avenue and University Street\n			Bus 356 stops at Sherbrooke Street and Uni
 versity Street (Nightbus)\n			Bus 107 stops at Pine Avenue and Docteur Penfie
 ld\n			Bus 24 stops at Sherbrooke Street and University Street\n		\n\n		Metro\n\n
 		Take the Metro Green Line to the 91ÉçÇø station. Walk north on University 
 Street and cross Pine Avenue. The main entrance is on the right\, past the
  flags.\n\n		Jeanne Timmins Amphitheatre\n\n		\n			Enter the main lobby\, turn le
 ft\, and go down the hallway to the end.\n			Turn right and go down the secon
 d hallway until you see another hallway on the left.\n			This hallway leads t
 o the Jeanne Timmins Foyer.\n			On your right are the Jeanne Timmins Amphithe
 atre entrance doors.\n		\n	\n	\n\n	\n		Sponsors \n	\n	\n\n	\n		Committee\n\n		Boris Bern
 hardt\n\n		Sam Audrain\n\n		Alexander Barnett\n\n		Sara Lariviere\n\n		Raluca Pana
 \n\n		Myriam Srour\n\n		Debbie Rashcovsky\n\n		 \n\n		 \n\n		 \n\n		 \n\n		\n	\n\n
DTSTART;VALUE=DATE:20260528
DTEND;VALUE=DATE:20260528
LOCATION:Jeanne Timmins Amphitheatre\, The Neuro
SUMMARY:Neuro Epilepsy Day and Pierre Gloor Lecture 2026
URL:/bic/channels/event/neuro-epilepsy-day-and-pierre-
 gloor-lecture-2026-367958
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